The Role of Oxidative Stress and Inflammation in Hypertension: Mechanisms, Therapeutic Targets, and Future Directions

Nader Hamdan Hamoud Aloufi
Mohmmed Masad Ghali Almutairi
Enas Ibrahim Ali Dandini
Alahmadi Naif Muqaybil S
Maher Oudah Suleiman Alqayidi
Merfat Mohammed O Taha
Rayid Marzouq Aljohani
Fayez Mohsen Tawhari
Eiadah Awad Ealtaqtaqi
Omar Hamid Alsobhi
Mohammed Salman Almuzaini
Hussain Saleh Aljoheni
Bander Jumah Aloufi
Abdullah Mousa Essa Alahmadi
Ahmed Suwayyid Almalki

Abstract

Hypertension is a multifactorial condition characterized by elevated blood pressure, where oxidative stress and inflammation play central roles. This article explores the intricate relationship between these two processes, detailing how they contribute to endothelial dysfunction, vascular remodeling, and renal impairment, all of which exacerbate hypertension. The renin-angiotensin system (RAS) and sympathetic nervous system (SNS) also interact with oxidative stress and inflammation, promoting vasoconstriction and sodium retention. Current therapeutic strategies targeting oxidative stress and inflammation, including antioxidants, anti-inflammatory compounds, and dietary interventions, show promise in managing hypertension. Future directions include investigating molecular pathways like Nrf2 and NF-κB, which may provide new therapeutic targets for reducing inflammation and oxidative stress.

How to Cite

Nader Hamdan Hamoud Aloufi, Mohmmed Masad Ghali Almutairi, Enas Ibrahim Ali Dandini, Alahmadi Naif Muqaybil S, Maher Oudah Suleiman Alqayidi, Merfat Mohammed O Taha, … Ahmed Suwayyid Almalki. (2024). The Role of Oxidative Stress and Inflammation in Hypertension: Mechanisms, Therapeutic Targets, and Future Directions . EVOLUTIONARY STUDIES IN IMAGINATIVE CULTURE, 537–565. https://doi.org/10.70082/esiculture.vi.2370