Nader Hamdan Hamoud Aloufi
Prince Sultan Armed Forces Hospital in Madinah, Aldifa, Madinah -42375, Saudi Arabia
Mohmmed Masad Ghali Almutairi
Prince Sultan Armed Forces Hospital in Madinah, Aldifa, Madinah -42375, Saudi Arabia
Enas Ibrahim Ali Dandini
Prince Sultan Armed Forces Hospital in Madinah, Aldifa, Madinah -42375, Saudi Arabia
Alahmadi Naif Muqaybil S
Prince Sultan Armed Forces Hospital in Madinah, Aldifa, Madinah -42375, Saudi Arabia
Maher Oudah Suleiman Alqayidi
Prince Sultan Armed Forces Hospital in Madinah, Aldifa, Madinah -42375, Saudi Arabia
Merfat Mohammed O Taha
Prince Sultan Armed Forces Hospital in Madinah, Aldifa, Madinah -42375, Saudi Arabia
Rayid Marzouq Aljohani
Albad General Hospital, Al Bad' 49814, Tabuk, Saudi Arabia
Fayez Mohsen Tawhari
Al-Mithnab General Hospital, Prince Faisal Ibn Bandar St, Alrayyan Al Sharqy, Al Mithnab-56526, Al-Qassim, Saudi Arabia
Eiadah Awad Ealtaqtaqi
Ashwaq general hospital, Ashwaq 49444, Tabuk, 8756, Saudi Arabia
Omar Hamid Alsobhi
Regional Blood Bank, 2981 Khalid Ibn Al Walid Rd, Madinah 42351, Saudi Arabia
Mohammed Salman Almuzaini
Regional Blood Bank, 2981 Khalid Ibn Al Walid Rd, Madinah 42351, Saudi Arabia
Hussain Saleh Aljoheni
Regional Blood Bank, 2981 Khalid Ibn Al Walid Rd, Madinah 42351, Saudi Arabia
Bander Jumah Aloufi
Regional Blood Bank, 2981 Khalid Ibn Al Walid Rd, Madinah 42351, Saudi Arabia
Abdullah Mousa Essa Alahmadi
Regional Blood Bank, 2981 Khalid Ibn Al Walid Rd, Madinah 42351, Saudi Arabia
Ahmed Suwayyid Almalki
Al Qara General Hospital, Albaha health cluster, Al Bahah Province, Alqari, BCJA4158, Saudi Arabia
Abstract
Hypertension is a multifactorial condition characterized by elevated blood pressure, where oxidative stress and inflammation play central roles. This article explores the intricate relationship between these two processes, detailing how they contribute to endothelial dysfunction, vascular remodeling, and renal impairment, all of which exacerbate hypertension. The renin-angiotensin system (RAS) and sympathetic nervous system (SNS) also interact with oxidative stress and inflammation, promoting vasoconstriction and sodium retention. Current therapeutic strategies targeting oxidative stress and inflammation, including antioxidants, anti-inflammatory compounds, and dietary interventions, show promise in managing hypertension. Future directions include investigating molecular pathways like Nrf2 and NF-κB, which may provide new therapeutic targets for reducing inflammation and oxidative stress.