Postoperative Thrombosis and Its Investigations: An Overview of Pathophysiology, Natural Coagulation Inhibitors, Risk Factors and Laboratory Investigations

Abstract

Background: One of the most frequent and fatal complications post-surgery is thrombosis or Deep Vein Thrombosis (DVT). It encompasses both deep vein thrombosis (DVT) and pulmonary embolism (PE), which can lead to considerable morbidity and mortality if undiagnosed or untreated. Understanding the clinical features and diagnostic approach, including laboratory investigations, is critical in managing this condition effectively. DVT can lead to serious complications like pulmonary embolism, venous gangrene, and post-thrombotic syndrome to name a few. These complications affect the post-recovery journey and overall quality of life of the patient. Objective: This review aims at overviewing the Thrombosis, associated risk factors, and corresponding lab investigations. Methods: The review is comprehensive research of PUBMED and Google scholar from the year 1965 to 2024. Conclusion: Multidisciplinary collaboration among surgeons, physicians, and laboratory specialists is vital to optimize outcomes and reduce the burden of thrombotic complications in postoperative patients.