Synergistic Approaches to Combatting Polymyxin-Resistant Microbial Strains in Hospital Settings: Diagnostics, Clinical Outcomes, Policy Implications and Current Challenges in Treating

Saeed Saad Hammad Aloufi, Abdullah Rached Aljohani, Essa Rashed Awadh Alsuhaymi, Abdullah Ayidh Muidh Alrehaili, Abdulmajeed Mohammed Aali Alalawi, Faris Nasser Attallah Alahmdi, Hassan Readh Alhajuj, Hamed Mohammed Aali Alalawi
Ayman Mohammed Salem Al-Twaim, Yuosef Ahmed Sulmain Duwayriat, Maged Mohammad Saliem Al Salih, Mohammed Ahmed Abdullh Alkurdi, Mansour Abdullah F Alfuraydi, Bandar Mohammed Alharbi, Turki Mohammed Turki Alanzi

Abstract

Polymyxins include polymyxin B and colistin, antibiotics which have played a crucial role as last resorts in the treatment of drug-resistant Gram-negative bacterial infections. Nevertheless, the increasing emergence of strains resistant to polymyxins has posed considerable clinical treatment challenges that risk the world's public health. Such resistance mechanisms include lipid A modification, efflux pumps, and plasmid-mediated mcr genes. These mechanisms render the polymyxins less potent, thus complicating infection control in clinical settings, especially hospitals. The present strategies against resistance are combination therapies: polymyxin with β-lactams, EDTA adjuvants, non-antibiotic approaches-nanoparticles, and phage therapy. Better diagnostics together with antimicrobial stewardship programs will control the spreading of resistance. MALDI-TOF and Rapid Polymyxin NP test can rapidly diagnose the diseases that can treat quickly. The development of solutions like host-based therapies, immunotherapy, and safer polymyxin analogues will be useful to cope with this crucial challenge. It pays more attention toward research and development of the novel therapy for polymyxin-resistant infections by providing much emphasis on global cooperation as well as government policies on combating the problem of antimicrobial resistance.

How to Cite

Saeed Saad Hammad Aloufi, Abdullah Rached Aljohani, Essa Rashed Awadh Alsuhaymi, Abdullah Ayidh Muidh Alrehaili, Abdulmajeed Mohammed Aali Alalawi, Faris Nasser Attallah Alahmdi, Hassan Readh Alhajuj, Hamed Mohammed Aali Alalawi, & Ayman Mohammed Salem Al-Twaim, Yuosef Ahmed Sulmain Duwayriat, Maged Mohammad Saliem Al Salih, Mohammed Ahmed Abdullh Alkurdi, Mansour Abdullah F Alfuraydi, Bandar Mohammed Alharbi, Turki Mohammed Turki Alanzi. (2024). Synergistic Approaches to Combatting Polymyxin-Resistant Microbial Strains in Hospital Settings: Diagnostics, Clinical Outcomes, Policy Implications and Current Challenges in Treating . EVOLUTIONARY STUDIES IN IMAGINATIVE CULTURE, 1516–1535. https://doi.org/10.70082/esiculture.vi.2776