This article analyzes Toole’s novel from a causal perspective, focusing on the cause-effect dynamics that make the plot advance, from the initial event at D.H. Holmes until the outcome in the Night of Joy. A combination of qualitative and quantitative methodologies has been applied to identify a series of 47 causal events that summarize all actions with an impact on plot development. Our research shows that the causal study of the novel is a useful approach that can reinforce or modify qualitative assessments of previous studies. The relevance of “Night of Joy” plot within the whole narrative and its key role in the rest of the subplots are verified in numerical terms. Besides, we have expanded and quantified the causal chains operating in the novel; and we have made sure, as well, that every subplot is essential in order to reach the final outcome (with the only exception of Dr. Talc’s story). Finally, we have formulated an alternative outline of secondary plots than the ones supported by preceding research by using numeric metrics, demonstrating that “Paradise Vendors” and “Dorian Greene”, previously considered secondary storylines, exert a high impact on Confederacy’s finale, and are, perhaps, not so secondary plots after all.